Mental functioning:

When and Where a mind "runs smoothly" and When and Where a mind doesn't "run smoothly";

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The onset of schizophrenia:

(Intuitiv und vermutlich falsch)

~ When the system which orchestrates neuronal activities breaks down.

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"So for Kraepelin the dementia associated with dementia praecox reflected dissolution of function in which higher mental centres no longer controlled lower levels, leading to 'loss of mastery over volition' and 'loss of ability for independent action'. Allowing for the difference in terminology, this sounds remarkably like a description of failure in what we would now call the 'central executive' - a higher level cognitive system for selecting and initiating appropriate actions to be carried out by lower-level 'slave' systems. ... this formulation of the core cognitive deficit associated with schizophrenia was reintroduced by neuropsychologists at the end of the 20th century."