Some notes and speculations about various topics. ||| Gegenwärtig - vorübergehend -
wohl eher eine Gedankensammlung als ein Naturwissenschaftsblog. Das Konzept eines "Naturwissenschaftsblogs" wird erst im kommenden Jahr (2018/2019) Umsetzung finden.
Donnerstag, 10. März 2016
Schizophrenia patients with high intelligence: A clinically distinct sub-type of schizophrenia?
Schizophrenia patients with high intelligence: A clinically distinct sub-type of schizophrenia? E. Cernis, E. Vassos, G. Brebion, P.J. McKenna, R.M. Murray, A.S. David,
J.H. MacCabe; (2015)
Schizophrenia patients are typically found to have low IQ both pre- and post-onset, in
comparison to the general population. However, a subgroup of patients displays above average IQ pre-onset.
The nature of these patients’ illness and its relationship to typical schizophrenia is not well
understood. The current study sought to investigate the symptom profile of high-IQ schizophrenia
We identified 29 schizophrenia patients of exceptionally high pre-morbid intelligence (mean
estimated pre-morbid intelligence quotient (IQ) of 120), of whom around half also showed minimal
decline (less than 10 IQ points) from their estimated pre-morbid IQ. We compared their symptom scores
(SAPS, SANS, OPCRIT, MADRS, GAF, SAI-E) with a comparison group of schizophrenia patients of typical
IQ using multinomial logistic regression.
The patients with very high pre-morbid IQ had significantly lower scores on negative and
disorganised symptoms than typical patients (RRR = 0.019; 95% CI = 0.001, 0.675, P = 0.030), and showed
better global functioning and insight (RRR = 1.082; 95% CI = 1.020, 1.148; P = 0.009). Those with a
minimal post-onset IQ decline also showed higher levels of manic symptoms (RRR = 8.213; 95%
CI = 1.042, 64.750, P = 0.046).
These findings provide evidence for the existence of a high-IQ variant of schizophrenia that
is associated with markedly fewer negative symptoms than typical schizophrenia, and lends support to
the idea of a psychosis spectrum or continuum over boundaried diagnostic categories.