My Science - Blog / Mein Naturwissenschaftsblog

Hopefully some interesting bits of information extracted from science and non-fiction literature. (For historical reasons there are some poems scattered throughout this blog.) Sachthemen und Sachtexte. (Historisch finden sich auf diesem Blog auch einige Gedichte und Aphorismen.) [Just collecting some exciting bits of information here.] [Eine Sammlung von interessanten Texten, Fragen und Antworten will das hier sein. Nicht mehr, aber auch nicht weniger.]

Dienstag, 5. März 2013

Dysfunction of the prefrontal cortex in addiction

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
R Z Goldstein & Nora D Volkow, 2011
http://www.nature.com/nrn/journal/v12/n11/full/nrn3119.html

Abstract

The loss of control over drug intake that occurs in addiction was initially believed to result from disruption of subcortical reward circuits. However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness). This Review focuses on functional neuroimaging studies conducted in the past decade that have expanded our understanding of the involvement of the PFC in drug addiction. Disruption of the PFC in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will.

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