James Y. Zou, Danny S. Park, Esteban G. Burchard, Dara G. Torgerson, Maria Pino-Yanes, Yun S. Song,
Sriram Sankararaman, Eran Halperin, and Noah Zaitlen; (2015)
Abstract
Nonrandom mating in human populations has important implications
for genetics and medicine as well as for economics and sociology.
In this study, we performed an integrative analysis of a large cohort of
Mexican and Puerto Rican couples using detailed socioeconomic
attributes and genotypes. We found that in ethnically homogeneous
Latino communities, partners are significantly more similar in their
genomic ancestries than expected by chance. Consistent with this, we
also found that partners are more closely related—equivalent to between
third and fourth cousins in Mexicans and Puerto Ricans—than
matched random male–female pairs. Our analysis showed that this
genomic ancestry similarity cannot be explained by the standard socioeconomic
measurables alone. Strikingly, the assortment of genomic
ancestry in couples was consistently stronger than even the assortment
of education. We found enriched correlation of partners’ genotypes
at genes known to be involved in facial development. We
replicated our results across multiple geographic locations. We discuss
the implications of assortment and assortment-specific loci on disease
dynamics and disease mapping methods in Latinos.
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