Increased Infectious Disease Susceptibility Resulting from Outbreeding Depression
Tony L Goldberg et al.; April 2005
Conservation Biology
Abstract
The mechanisms by which outbreeding depression leads to reduced fitness are poorly understood. We considered the hypothesis that outbreeding can depress fitness by increasing the susceptibility of hybrid individuals and populations to infectious disease. Competitive breeding trials in experimental ponds indicated that outbred largemouth bass ( Micropterus salmoides) crossed from two geographically and genetically distinct populations suffered a reduction in fitness of approximately 14% relative to parental stocks. We measured the comparative susceptibility of these same outbred stocks to a novel viral pathogen, largemouth bass virus. Following experimental inoculation, F2 generation hybrids suffered mortality at a rate 3.6 times higher than either F1 generation hybrids or wild-type parental fish. Analysis of viral loads indicated that viral replication was more rapid in F2 fish than in F1 hybrids or wild-type parental fish. We attribute these results to the disruption of coadapted gene complexes in the immune systems of outbred fish in the F2 generation. Increased susceptibility to infectious disease may be an important but underappreciated mechanism by which outbreeding reduces the fitness of individuals and populations and by which novel infectious diseases emerge in populations of hybrid organisms.
Hopefully some interesting bits of information extracted from science and non-fiction literature. (There are also some poems and aphorisms scattered throughout this blog.) Sachthemen und Sachtexte. (Zusätzlich finden sich hier einige Gedichte und Aphorismen.) [This blog reflects, in a semi-autistic way, some bits of information which I enjoyed very much.] [Was hängenbleibt oder mal länger durch den Kopf geht wird hier notiert.]
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